|
T3174 |
Taprenepag
|
CP-544326 |
Prostaglandin Receptor
|
|
Taprenepag (CP-544326) (CP-544326) is a potent and selective prostaglandin E2 receptor agonist (EC50 = 2.8 nM). Taprenepag has been used in trials studying the treatment of Ocular Hypertension and Glaucoma, Open-Angle. |
|
T12670 |
(Rac)-MGV354
|
MGV354 |
Others
|
|
(Rac)-MGV354 (MGV354) is the racemate of MGV354. MGV354 is a soluble activator of guanylate cyclase (sGC)(EC50s of <0.5 nM, and 5 nM in CHO and GTM-3 E cells, respectively). |
|
T0142 |
Brinzolamide
|
AL-4862 |
Carbonic Anhydrase
|
|
Brinzolamide (AL-4862) is a Carbonic Anhydrase Inhibitor. The mechanism of action of brinzolamide is as a Carbonic Anhydrase Inhibitor. |
|
T0106 |
Methazolamide
|
L584601,CL 8490 |
Carbonic Anhydrase
|
|
Methazolamide (CL 8490) is a carbonic anhydrase inhibitor that is used as a diuretic and in the treatment of glaucoma. |
|
T60924 |
Verosudil
|
AR-12286 |
ROCK
|
|
Verosudil (AR-12286) is a highly potent Rho kinase (ROCK) inhibitor with a Ki of 2 and 2 nM against ROCK1 and ROCK2, respectively. AR-12286 reverses steroid-induced intraocular pressure in mice by decreasing intraocular ... |
|
T6422 |
Brimonidine Tartrate
|
AGN190342 tartrate,304 tartrate,AGN190342 (tartrate),UK 14304 (tartrate),UK14304 tartrate |
Adrenergic Receptor
|
|
Brimonidine Tartrate (AGN190342 tartrate) is a quinoxaline derivative and adrenergic α-2 receptor agonist (EC50: 0.45 nM) that is used to manage intraocular pressure associated with open-angle glaucoma or ocular hyperten... |
|
T19870 |
Aceclidine
|
3-Acetoxyquinuclidine,1-azabicyclo[2.2.2]octan-3-yl acetate,NSC657843,3-quinuclidinyl acetate,NSC-657843,Glaucostat,NSC 657843,Quinuclidin-3-yl acetate |
AChR
|
|
Aceclidine (1-azabicyclo[2.2.2]octan-3-yl acetate) is a modulator of M3 mAChR and can be used in studies about treating glaucoma by reducing intraocular pressure. |
|
T10358 |
Netarsudil Dihydrochloride
|
AR-13324 Dihydrochloride |
ROCK
|
|
Netarsudil Dihydrochloride (AR-13324 Dihydrochloride) is an inhibitor of Rho-associated protein kinase (ROCK) and norepinephrine transporter (NET) with effective in intraocular pressure (IOP) reduction. |
|
T21371 |
Apraclonidine hydrochloride
|
Iopidine,ALO 2145,Apraclonidina,P-aminoclonidine,4-Aminoclonidine,Apraclonidine HCl,Apraclonidinum |
Adrenergic Receptor
|
|
Apraclonidine hydrochloride (ALO 2145) is an α2-adrenergic agonist and a weak α-1 adrenergic receptor agonist. Apraclonidine hydrochloride lowers intraocular pressure in human eyes and can be used in studies about glauco... |
|
T15719 |
Latanoprostene bunod
|
LBN,NCX116 |
Others
|
|
Latanoprostene bunod (LBN) is nitric oxide (NO)-donating prostaglandin F2a analog and is a topical ophthalmic therapeutic. It is used for the reduction of intraocular pressure (IOP) in patients with open-angle glaucoma o... |
|
T22029 |
AL 34662
|
|
5-HT Receptor
,
Adrenergic Receptor
|
|
AL 34662 is a selective and potent 5-HT2A receptor agonist with IC50s of 0.77 nM and 1.5 nM for rat and human 5-HT2 receptors, respectively.AL 34662 is also a low affinity α-1D adrenergic agonist, with an EC50 of 0.4 μM.... |
|
T2403 |
Bromfenac sodium hydrate
|
Bromfenac sodium,Bromfenac monosodium salt sesquihydrate |
COX
|
|
Bromfenac sodium hydrate (Bromfenac monosodium salt sesquihydrate) is the sodium salt form of bromfenac, a nonsteroidal anti-inflammatory drug (NSAID) with analgesic and anti-inflammatory activities. Upon ophthalmic admi... |
|
T25483 |
H-0106 Dihydrochloride
|
H 0106 2HCl,H0106 2HCl,H0106 Dihydrochloride |
|
|
H-0106 Dihydrochloride is an inhibitor of ROCK that acts by applying strong intraocular pressure (IOP)-lowering effects into the eyes of monkeys. |
|
T13955 |
Unoprostone
|
|
Others
|
|
Unoprostone is a prostaglandin F2α analogs (PGAs), and reduces intraocular pressure and is used topically for glaucoma or ocular hypertension. |
|
T10358L2 |
Netarsudil mesylate
|
AR-13324 (mesylate) |
Others
|
|
Netarsudil mesylate is an inhibitor of Rho-associated protein kinase (ROCK) and norepinephrine transporter (NET) with effective in intraocular pressure (IOP) reduction. |
|
T25482 |
H-0104 Dihydrochloride
|
H0104 Dihydrochloride,H0104 2HCl,H 0104 Dihydrochloride,H 0104 2HCl,H-0104 2HCl |
|
|
H-0104 Dihydrochloride is an inhibitor of ROCK that acts by applying potent intraocular pressure (IOP)-lowering effects into the eyes of monkeys. |
|
T37991 |
15-keto Prostaglandin F2α
|
15-keto Prostaglandin F2α,15-keto PGF2α |
Endogenous Metabolite
,
Prostaglandin Receptor
|
|
15-keto Prostaglandin F2α is a metabolite of Prostaglandin F2α that lowers intraocular pressure in rabbits. |
|
T11821 |
Latanoprost lactone diol
|
|
Others
|
|
Latanoprost lactone diol is an important intermediate compound in the synthesis of Latanoprost. Latanoprost, classified as a prostaglandin F2α analogue, functions as an agonist for the FP prostanoid receptor, resulting i... |
|
T38196 |
Prostaglandin F2α isopropyl ester
|
Prostaglandin F2α isopropyl ester |
|
|
PGF2α isopropyl ester is an ester prodrug of PGF2α with enhanced lipid solubility. Due to better membrane penetration, PGF2α isopropyl ester is more suitable than PGF2α or PGF2α tromethamine salt for topical application ... |
|
T71120 |
AR-13503
|
|
|
|
AR-13503, is an metabolite of Netarsudil (AR-11324), is a Rho-associated protein kinase inhibitor. Netarsudil is potential useful for treating glaucoma and/or reducing intraocular pressure. |
|
T60807 |
Cannabicitran
|
|
|
|
Cannabicitran is a cannabinoid that can decrease rabbits intraocular pressure [1] [2]. |
|
T19682 |
Levobetaxolol
|
(S)-(-)-Betaxolol,(S)-Betaxolol |
|
|
Levobetaxolol, also known as AL-1577A and Betaxon, is a cardioselective β-adrenergic receptor inhibitor. It has been demonstrated to reduce intraocular pressure in patients affected by ocular hypertension and primary ope... |
|
T28126 |
Nabitan hydrochloride
|
Benzopyranoperidine,A-40656,A40656,SP-106,A 40656,Nabutam |
|
|
Nabitan hydrochloride is a synthetic cannabinoid analog with antiemetic and analgesic effects. It may bind to and activate the CB1 and CB2 cannabinoid receptors. It also reduces intraocular pressure and may be useful in ... |
|
T10357 |
AR-13324 analog mesylate
|
|
Others
|
|
AR-13324 analog mesylate is an inhibitor of Rho-kinase and a norepinephrine transporter and reduces intraocular pressure in normotensive monkey eyes. |
|
T61216 |
Dichlorphenamide disodium
|
|
|
|
Dichlorphenamide disodium is a specific, orally active carbonic anhydrase inhibitor. It effectively reduces intraocular pressure by impeding the secretion of aqueous humor. Notably, dichlorphenamide disodium holds potent... |
|
T60848 |
Carbonic anhydrase inhibitor 3
|
|
|
|
Carbonic anhydrase inhibitor 3 (compound 11g) is an inhibitor of carbonic anhydrase II that reduces the intraocular pressure in glaucomatous rabbits [1]. |
|
T75155 |
Bamosiran
|
|
|
|
Bamosiran, a small interfering RNA (siRNA), specifically targets the β-adrenergic receptor 2 to reduce intraocular pressure. |
|
T38198 |
Prostaglandin F2α methyl ester
|
|
|
|
Prostaglandin F2α methyl ester is a highly lipid-soluble PGF2α analog used to maintain low intraocular pressure. |
|
T38194 |
Prostaglandin E3
|
PGE3 |
|
|
Prostaglandin E3 (PGE3) is formed via the cyclooxygenase (COX) metabolism of eicosapentaenoic acid. [1] In human ocular tissue, it comprises 2.4% of the COX products formed. [1] When applied to the eyes of a rabbit, a ... |
|
T61120 |
Carbonic anhydrase inhibitor 2
|
|
|
|
Compound 7c, identified as carbonic anhydrase inhibitor 1, effectively inhibits carbonic anhydrase II. This inhibitor, also known as carbonic anhydrase inhibitor 3, lowers intraocular pressure in glaucomatous rabbits [1]... |
|
T37956 |
Tafluprost ethyl amide
|
|
|
|
Tafluprost ethyl amide is a prostaglandin derivative. Tafluprost ethyl amide reduces intraocular pressure (IOP) and affects eyelash growth. Tafluprost ethyl amide can be used in anti-glaucoma eye drops and cosmetics. |
|
T70735 |
Verosudil hydrochloride
|
|
|
|
Verosudil, also known as AR-12286, is a potent and selective Rho kinase inhibitor. AR-12286 was well tolerated and provided statistically significant reduction in IOP (intraocular pressure) in patients with XFS (exfolia... |
|
T60350 |
Apraclonidine
|
|
|
|
Apraclonidine (ALO 2145) is a selective α2 and weak α1 receptor agonist that effectively lowers intraocular pressure (IOP) in human eyes. Apraclonidine is a topical ophthalmic solution [1] [2]. |
|
T61180 |
GAT564
|
|
|
|
GAT564 (Compound 15d) is a highly effective allosteric modulator of cannabinoid 1 receptor (CB1R), having EC50 values of 87 nM and 320 nM for cAMP and β-arrestin2, respectively. It significantly enhances the binding of o... |
|
T36145 |
12(R)-HETE
|
|
|
|
Biosynthesis of 12(R)-HETE in invertebrates is via lipoxygenation of arachidonic acid . In mammals, 12(R)-HETE can be produced by 12(R)-LOs and also by CYP450 oxidation. The activity of 12(R)-HETE in mammals is predomina... |
|
T62036 |
Sovesudil
|
|
|
|
Sovesudil (PHP-201) is a potent, ATP-competitive, locally acting Rho kinase (ROCK) inhibitor. Sovesudil shows IC50 s of 3.7 and 2.3 nM for ROCK-I and ROCK-II, respectively. Sovesudil can lower intraocular pressure (IOP) ... |
|
T64241 |
Brinzolamide hydrochloride
|
|
|
|
Brinzolamide (AL-4862) hydrochloride is a selective inhibitor (IC50: 3.2 nM) of carbonic anhydrase II. Brinzolamide hydrochloride inhibits ciliary CA-II and reduces atrial fluid secretion, thereby reducing intraocular pr... |
|
T16388 |
Omidenepag isopropyl
|
|
Prostaglandin Receptor
|
|
|
|
T63637 |
ROCK-IN-4
|
|
|
|
ROCK-IN-4 is a potent inhibitor of ROCK and maintains NO release capacity.ROCK-IN-4 reversibly depolymerizes F-actin and blocks mitochondrial respiration in human trabecular meshwork (HTM) cells.ROCK-IN-4 can be used to ... |
|
T73083 |
Nipradolol
|
KT 210 ; K 351 ; Hypadil,Hypadil,KT 210,K 351 |
|
|
Nipradolol (KT-210; K-351), an alpha-1-adrenergic receptor antagonist, effectively inhibits the elevation of intraocular pressure (IOP) induced by Phenylephrine in an albino rabbit model and suppresses noradrenaline (NA)... |
|
T74736 |
2MD
|
|
|
|
2MD, an orally active vitamin D analog, both stimulates periosteal bone formation and decreases trabecular bone resorption, effectively restoring trabecular and cortical bone mass and strength. Additionally, 2MD regulate... |
|
T38113 |
AL 6598
|
|
|
|
Elevated intraocular pressure (IOP) is an important risk factor in developing glaucoma. Certain prostaglandins such as PGF2α and PGD2, have been shown to reduce IOP. AL 6598 is the isopropyl ester prodrug of AL 6556, a P... |
|
T36908 |
Bimatoprost grenod
|
15-(6-nitroxyhexanoyl)-17-phenyl trinor Prostaglandin F2α |
|
|
Bimatoprost grenod(15-(6-nitroxyhexanoyl)-17-phenyl trinor PGF2α) is a nitric oxide-donating derivative of 17-phenyl trinor PGF2α.1It increases cGMP levels in rabbit aqueous humor and iris ciliary body when topically adm... |
|
T37935 |
16-phenoxy tetranor Prostaglandin F2α cyclopropyl methyl amide
|
16-phenoxy tetranor Prostaglandin F2α cyclopropyl methyl amide |
|
|
The actions of many clinical F-series prostaglandins (PGs), including those used for estrous synchronization and for reduction of intraocular pressure (IOP), are mediated through the PGF2α (FP) receptor. 16-phenoxy tetra... |
|
T37941 |
17-phenyl trinor Prostaglandin F2α cyclopropyl methyl amide
|
17-phenyl trinor Prostaglandin F2α cyclopropyl methyl amide |
|
|
Prostaglandin F2α (PGF2α) activates the FP receptor, promoting smooth muscle contraction and luteolysis. 17-phenyl trinor PGF2α binds the FP receptor on ovine luteal cells with a relative potency of 756% compared to that... |
|
T71119 |
Netarsudil free base
|
|
|
|
Netarsudil, also known as AR-11324, is a Rho-associated protein kinase inhibitor. Netarsudil is potential useful for treating glaucoma and/or reducing intraocular pressure. Netarsudil Increases Outflow Facility in Hum... |
|
T36059 |
Dichlorphenamide-13C6
|
Dichlorphenamide-13C6 |
|
|
Dichlorphenamide-13C6is intended for use as an internal standard for the quantification of dichlorphenamide by GC- or LC-MS. Dichlorphenamide is a sulfonamide and an orally bioavailable carbonic anhydrase (CA) inhibitor ... |
|
T70186 |
Methazolamide-d6
|
|
|
|
Methazolamide-d6 is intended for use as an internal standard for the quantification of methazolamide by GC- or LC-MS. Methazolamide is a carbonic anhydrase inhibitor. It reduces intraocular pressure and cerebrospinal flu... |
|
T37933 |
15-keto Latanoprost (free acid)
|
|
|
|
15-keto Latanoprost is a potential metabolite of latanoprost when administered to animals. 15-keto Latanoprost is also one of the common minor impurities found in commercial preparations of the bulk drug compound. Althou... |
|
T38204 |
GAT229
|
|
|
|
GAT229 is a positive allosteric modulator of cannabinoid receptor 1 (CB1) and the S-(-) enantiomer of the CB1 modulator GAT211. It does not activate the receptor on its own but enhances the binding and activity of CB ago... |
